PRF is NOT the same as stem cell therapy
While PRF contains small amounts of mesenchymal stem cells, its primary mechanism of action is through platelet-derived growth factors, not stem cell regeneration. PRF enhances healing by stimulating the body’s natural repair processes rather than introducing new cells that differentiate into tissues.
Feature | PRF (Platelet-Rich Fibrin) | PRP (Platelet-Rich Plasma) | Outside Stem Cells |
Source | Patient’s own blood | Patient’s own blood | Donor tissue (placenta, umbilical cord) or lab-grown |
Processing | Spun at a lower speed, no anticoagulants | Spun at a higher speed with anticoagulants | Lab-processed before use |
Platelet Concentration | High, with slow-release growth factors | High, but releases growth factors quickly | Varies depending on the source |
Growth Factor Release | Slow, sustained release over days | Fast release, short duration | May contain growth factors, but focus is on stem cell differentiation |
Cell Types Present | Platelets, white blood cells, small amounts of mesenchymal stem cells | Platelets, little to no white blood cells | High concentration of donated stem cells |
Risk of Rejection | None (your own cells) | None (your own cells) | Potential (not your own cells) |
Common Uses | Joint & tendon injuries, facial rejuvenation, hair restoration | Joint injuries, aesthetics, wound healing | Severe injuries, degenerative diseases |
Key Differences Between PRF and Stem Cells
1. PRF is Primarily Platelet-Based, Not Stem Cell-Based
PRF is derived entirely from the patient’s blood, without any external additives.
It contains platelets, fibrin, white blood cells, and some mesenchymal stem cells (MSCs) in low concentrations.
While MSCs are present in PRF, their numbers are far lower than in dedicated stem cell therapies.
2. PRF Works by Releasing Growth Factors, Not By Directly Replacing Cells
PRF helps stimulate the body's existing cells to repair tissues through growth factors like PDGF, TGF-β, and VEGF.
In contrast, stem cell therapy introduces new stem cells that can differentiate into different types of tissues (muscle, bone, cartilage, etc.).
3. PRF is a Blood Product; Stem Cells Come from Bone Marrow or Fat
PRF is obtained from a simple blood draw, spun in a centrifuge to concentrate platelets and fibrin.
Stem cells are typically harvested from bone marrow (hip) or adipose (fat) tissue, requiring a more invasive procedure.
4. PRF is Best for Healing and Repair, While Stem Cells Can Regenerate New Tissue
PRF accelerates healing by improving blood flow, reducing inflammation, and encouraging tissue regeneration.
Stem cell therapy actively regenerates new tissue by transforming into different cell types, making it better suited for severe degeneration or injuries.
Benefits of PRF Therapy
Longer-Lasting Growth Factor Release – PRF releases healing proteins over several days, unlike PRP, which disperses quickly.
No Additives Needed – PRF is 100% natural and does not require anticoagulants like PRP does.
Higher Platelet and Leukocyte Concentration – This enhances its regenerative potential.
Versatile Applications – PRF is commonly used in:
Orthopedics & Sports Medicine – Treating joint injuries, tendonitis, muscular tears, Ligament injuries and osteoarthritis.How We Use It:At our office, we use PRF to accelerate healing from soft tissue injuries. Whether it's a strained muscle, tendon, or ligament issue, PRF injections can promote tissue repair and reduce pain. Using ultrasound guidance, we precisely inject the patient’s own PRF directly into the injured area, enhancing the body’s natural healing process. Most patients experience significant relief within 1 to 3 treatments.
Aesthetic Medicine – Facial rejuvenation (wrinkle reduction, increased collagen), hair restoration, scaring treatment.How We Use It:We combine PRF with microneedling to deliver growth factors into the top layers of the skin. This stimulates collagen production, improves skin texture, reduces wrinkles, and accelerates scar healing. PRF is also used for hair restoration, where it nourishes hair follicles and promotes natural regrowth.
Wound Healing – Improving recovery from chronic wounds and surgical incisions.
Other: Joint pain, Muscle strains, Rotator cuff tears. Achilles tendon ruptures, Ankle Sprain, Tendonitis, Tennis/Golfers elbow, Ligament damage, Soft tissue injuries, Hair growth, Erectile Dysfunction, Wrinkle reduction, Healing scar tissue
Watch our Patient Testimonials:
Is PRF Therapy right for you?
If you’re looking for a natural, non-surgical way to support healing, reduce pain, or enhance your skin and hair, PRF therapy may be the right choice for you. Whether you’re recovering from a joint injury, struggling with tendon pain, or seeking facial rejuvenation, PRF harnesses your body’s own healing potential to deliver lasting results.
At The Logan Institute, we specialize in cutting-edge regenerative therapies, using only your own cells to maximize safety and effectiveness. Our expert team will assess your condition and create a personalized treatment plan to help you feel and function at your best.
If you’re ready to take the next step toward healing, contact us today to learn more about how PRF therapy can work for you!
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